Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds
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چکیده
منابع مشابه
Small Molecule Therapeutics Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies
Activatingmutations inPTPN11 (encodingSHP2), a protein tyrosinephosphatase (PTP) that plays anoverall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of Noonan syndrome and childhood leukemias. Identification of SHP2-selective inhibitors could lead to the development of new drugs that ultimately serve as treatments for PTPN11-associated disea...
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Synapse-specific expression of the nicotinic acetylcholine receptor (AChR) is believed to be mediated by neuregulin, an epidermal growth factor-like trophic factor released by somatic motoneurons at the neuromuscular junction (NMJ). Neuregulin stimulates ErbB2, ErbB3, and ErbB4, members of the ErbB family of receptor tyrosine kinases. SHP2 is a cytoplasmic protein tyrosine phosphatase containin...
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Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways. We have found that the protein tyrosine phosphatase Shp2 regulates the strength and duration of phos...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2020
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2020.06.002